L-α-dipeptides (dipeptides) ha e so ithutoe hoo e batlang e le bongata bo nang le liprotheine le li-amino acid.Patlisiso ea mantlha e entsoe ka L-aspartyl-L-phenylalanine methylester (aspartame) le Ala-Gln (Lalanyl-L-glutamine) hobane li sebelisoa lihlahisoa tse tsebahalang tsa khoebo.Ntle le taba ena, lebaka le leng leo ka lona li-dipeptide tse ngata li sa kang tsa ithutoa ka botlalo ke hobane tlhahiso ea dipeptide ha e na ts'ebetso e sebetsang ea tlhahiso, leha ho tlalehiloe mekhoa e mengata ea lik'hemik'hale le chemoenzymatic.
Carnosine - mohlala oa dipeptide
Ho fihlela haufinyane tjena, ho entsoe mekhoa e mecha bakeng sa synthesis ea dipeptide eo dipeptide li hlahisoang ka eona ka mekhoa ea ho belisoa.Li-dipeptide tse ling li na le bokhoni bo ikhethang ba fisioloji, tse li lumellang ho potlakisa ts'ebeliso ea dipeptide mafapheng a fapaneng a lipatlisiso tsa mahlale.L-α-dipeptides e entsoe ka bond e sa rarahanang ea peptide ea li-amino acid tse peli, leha ho le joalo ha li fumanehe habonolo haholo-holo ka lebaka la ts'ebetso e bolokang chelete e ngata ea tlhahiso.Leha ho le joalo, li-dipeptides li na le mesebetsi e thahasellisang haholo, 'me boitsebiso ba saense bo ba potolohileng bo ntse bo eketseha.Sena se siea bafuputsi ba bangata ba na le tefiso ea ho nts'etsapele lits'ebetso tse sebetsang hantle le tse theko e tlase tsa tlhahiso ea dipeptide.Ha tšimo ena e ithutoa ka botlalo, ho lebelletsoe hore re ka ithuta haholoanyane ka hore na li-peptide li bohlokoa hakae.
Li-dipeptides li na le mesebetsi e 'meli ea mantlha, e leng:
1. Motsoako oa li-amino acid
2. Dipeptide ka boyona
Joalo ka e nkiloeng ho li-amino acid, dipeptides, hammoho le li-amino acid tsa tsona li na le thepa e fapaneng ea physiochemical, empa hangata li arolelana litlamorao tse tšoanang tsa 'mele.Sena se bakoa ke hore li-dipeptide li senyehile ho ba li-amino acid tse ka har'a lintho tse phelang, tse nang le litšobotsi tse fapaneng tsa physicochemical.Ka mohlala, L-glutamine (Gln) ke mocheso-labile, ha Ala-Gin (L-alanyl-L-glutamine) e mamella mocheso.
Motsoako oa lik'hemik'hale oa dipeptide o hlaha ka tsela e latelang:
1. Lihlopha tsohle tsa dipeptide tse sebetsang li sirelelitsoe (ntle le tse amehang ho theheng peptide bond ea amino acid).
2. Amino acid e sirelelitsoeng ea sehlopha sa mahala sa carboxyl e kentsoe tšebetsong.
3. Asiti ea amino e kentsoeng e sebetsa le amino acid e 'ngoe e sirelelitsoeng.
4. Lihlopha tse sireletsang tse ka har'a dipeptide lia tlosoa.
Nako ea poso: Apr-19-2021
